Introduction and purpose: Assessing patients’ quality of life enables researchers to focus on key problems and apply the best treatment approaches. This study aimed to assess quality of life at hemodialysis patients hospitalized in HazratVali-Asr and Dr Beheshti hospitals in Zanjan city.

Materials and Methods: This cross-sectional study was conducted among 74 hemodialysis patients hospitalized in two centers of Zanjan city. Data were collected during three months using standardized quality of life questionnaire for patients with renal failure (KDQOL). This questionnaire composes of two parts including; questions related to quality of life short form(sf36) and questions related to factors associated with renal disease.

Findings: The results of this study showed that 8.1 percent of patients had poor quality of life, 70.2 percent had relatively good quality of life and 20.2 percent had a good quality of life. The highest score in the nine dimensions of quality of life belong to pain score (57.6%) and the lowest mean score attributed to physical health problems.

Conclusion: The results of this study provide valuable information for professionals and policy makers to enhance patients’ quality of life by strengthening and supporting policies.